The use of newer Hormonal Treatments

ATAC trial is comparing Anastrozole and Tamoxifen Alone or in Combination.

Intergroup Exemestane Study compares 5 years of Tamoxifen with 2-3 years Tamoxifen followed by 2-3 years Exemestane.

BIG 1-98 - The Breast International Group study compares Letrozole and Tamoxifen alone or the sequential use of these agents.

ZOFAST trial.    This study is for women taking Letrozole for early breast cancer treatment and evaluates whether bone density protection with Zometa should be started immediately or only if bone density drops by more than a certain amount.

FACE trial.   A head to head comparison of Letrozole and Anastrozole for postmenopausal women with hormone sensitive and lymph node positive early breast cancer.

SOFT (IBCSG 23-02) is testing the role of ovarian function suppression and the role of exemestane in premenopausal women.